IGF-1 RELEASE IN THE MEDIAL PREFRONTAL CORTEX MEDIATES THE RAPID AND SUSTAINED ANTIDEPRESSANT-LIKE ACTIONS OF KETAMINE

IGF-1 release in the medial prefrontal cortex mediates the rapid and sustained antidepressant-like actions of ketamine

Abstract Ketamine, an N-methyl-D-aspartate receptor antagonist, exerts rapid and sustained antidepressant actions.Preclinical studies demonstrated that the release of brain-derived neurotrophic factor (BDNF) and vascular endothelial growth factor in the medial prefrontal cortex (mPFC) is essential for the antidepressant-like effects of ketamine.How

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A Critical Comparison of Annual Glare Simulation Methods

Recently, there have been multiple proposals for faster methods to calculate glare metrics, daylight glare probability (DGP) in particular.This is driven simultaneously by the lengthy times required to simulate DGP with a conventional image-based climax blueberry cross pollination approach and accumulating evidence from subjective glare evaluation

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